The interleukin 28B gene polymorphism, rs8099917, in patients with chronic hepatitis C and response to the treatment with pegylated interferon and ribavirin
نویسندگان
چکیده
منابع مشابه
the role of interleukin-28b gene polymorphisms in chinese patients with chronic hepatitis c treated with pegylated interferon and ribavirin
patients and methods il28b rs8099917 was genotyped in 263 patients with hepatitis c virus (hcv) infection and 244 healthy controls in tianjin, china using taqman snp genotyping method. the roles of rs8099917 and clinical characteristics in antiviral treatment were analyzed by logistic regression. results among 263 patients with chronic hcv infection, 223 had a tt genotype (84.8%). frequencies o...
متن کاملThe Role of Interleukin-28b Gene Polymorphisms in Chinese Patients With Chronic Hepatitis C Treated With Pegylated Interferon and Ribavirin
BACKGROUND Interleukin-28B (IL28B) single nucleotide polymorphism (SNP) rs8099917 has been described to be associated with response to treatment with pegylated interferon and ribavirin (PEG-IFN/RBV) in patients with chronic hepatitis C from the North America, Europe, Asia countries like Japan and Taiwan. Whether this holds true for Chinese patients remains unknown. OBJECTIVES We aimed to stud...
متن کاملPolymorphism of IL-28B Gene (rs12979860) in HCV Genotype 1 Patients Treated by Pegylated Interferon and Ribavirin
Background: Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL-28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. Methods...
متن کاملInterleukin-28B genotypes determine response to pegylated-interferon plus ribavirin therapy in patients with hepatitis C virus infection.
We recently reported that the interleukin (IL)-28B major genotype is a predictor of early suppression of the hepatitis C virus (HCV) at 12 weeks in response to pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy. The present study investigated the relationship between IL-28 genotypes and the virological response to PEG-IFN/RBV therapy at 24 and 48 weeks. Genotypes of the IL-28B rs809991...
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ژورنال
عنوان ژورنال: Journal of Research in Medical Sciences
سال: 2019
ISSN: 1735-1995
DOI: 10.4103/jrms.jrms_621_18